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TripleFlex Facts Questions

Q. What is Glucosamine?
A. Glucosamine is an amino sugar produced by the body. It plays an important role in the production, maintenance, and replenishment of cartilage – an essential connective tissue in the joints that prevents the bones from grinding together.
Q. What is Chondroitin?
A. Chondroitin is a naturally occurring nutrient found in the connective tissues, which lubricate and cushion your joints. Chondroitin sulfate has been found to exert anti-inflammatory actions and has been used by itself or in combination with glucosamine to help improve and ease joint discomfort.
Q. What is MSM?
A. Methylsulfonylmethane or MSM is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains and in animals, including humans in at least trace amounts. Because MSM is a source of sulfur, it is essential for the formation of connective tissue. MSM has been studied and is often used for easing joint discomfort. In a 2004 clinical study on MSM, the authors conclude that the combination of MSM with glucosamine provides better and more rapid improvement in joint health.
Q. How long does it take to feel the effects of Triple Flex?
A. When taking Triple Flex, most people begin to feel an ease in discomfort in 4-6 weeks on average when taken daily.

For faster relief, try Triple Flex Rapid Relief with Lubravite™, which begins to naturally ease discomfort in as little as 7 days.

Q. Why are there different types of Triple Flex?
A. Triple Flex is available in three formulas developed to fit your different joint care needs:

a. Triple Flex Triple Strength with MSM-Improve joint function with a convenient 2 caplets a day formula with 1500 mg glucosamine, 800 mg Chondroitin, and 750 mg MSM.

b. Triple Flex Rapid Relief-Relieve joint comfort in 7 days through a unique combination of 1500 mg glucosamine, 750 mg MSM, and 500 mg Lubravite, a fast acting formula.

Q. I noticed TripleFlex Rapid Relief contains Lubravite. What is it and what does it do?
A. TripleFlex Rapid Relief is the only product that contains Lubravite, a new fast-acting, all-natural formulation. Lubravite contains a special blend of ginger and white willow bark, which begins to naturally ease joint discomfort in as little as 7 days. In fact, white willow bark has been used for 1,000s of years.
Q. Why is my TripleFlex Rapid Relief reddish/brown while other TripleFlex tablets are white?
A. Triple Flex comes in different formulas to fit your different joint care needs. Triple Flex Rapid Relief with Lubravite is reddish/brown to distinguish from the original Triple Flex formula, which comes in white tablets.
Q. The tablets are hard for me to swallow. May I cut it in half?
A. Yes, TripleFlex may be cut in half to help make it easier to swallow.
Q. Are all joint-health products the same? Why choose Nature Made TripleFlex?
A. No, not all joint health supplements are created equal. Nature Made TripleFlex follows stringent manufacturing practices to ensure what's on the label is in the bottle. In addition, TripleFlex is a national sponsor of the Arthritis Foundation.
Q. Is TripleFlex regulated by the FDA?
A. TripleFlex and all dietary supplements are regulated by the U.S. Food and Drug Administration, the Federal Trade Commission and government agencies in all 50 states.
Q. Where can I find more information on joint health?
A. The Wellness Advisor at www.NatureMade.com and the Arthritis Foundation at www.arthritis.org are good resources for joint health information.
Q. What clinical studies support Triple Flex?
A. The ingredients have been formulated by doctors and scientists. The ingredients found in Triple Flex Rapid Relief have been found to be beneficial for joint comfort in more than 20 high quality clinical studies.



REFERENCES

Glucosamine

Bruyere O, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 2004;11(2):138-143.

Christgau S, et al. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol 2004;22(1):36-42.

Cibere J, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum 2004;51(5):738-745.

Clegg DO, Reda DJ, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808.

Crolle G, et al. Glucosamine sulphate for the management of arthrosis: a controlled clinical investigation. Curr Med Res Opin 1980;7(2):104-109.

D'Ambrosio E, et al. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2(8):504-508.

Drovanti A, et al. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a placebo-controlled double-blind investigation. Clin Ther 1980;3(4):260-272.

Giordano N, et al. Efficacy and safety of glucosamine sulfate in the treatment of gonarthritis. Clin Therapeutics 1996;147:99-115.

Herrero-Beaumont G, Ivorra JA, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum 2007;56:555-567.

Lopes Vas A. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8(3):145-9.

Muller-Fassbender H, et al. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2(1):61-69.

Mund-Hoym WD. Conservative treatment of vertebral osteoarthritis with glucosamine sulfate. Therapiewoche 1980;30:5922-28.

Noack W, et al. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2(1):51-59.

Pavelka K, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162(18):2113-23.

Pujalte JM, et al. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7(2):110-114.

Qui GX, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48(5):469-474.

Reginster JY, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001;357(9252):251-256.

Reichelt A, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study. Arzneimittelforschung 1994;44(1):75-80.

Rovati LC. The clinical profile of glucosamine sulfate as a selective symptom modifying drug in osterarthritis: current data and perspectives. Osteoarthritis Cartilage 1997;5:72.

Rovati LC. Clinical research in osteoarthritis design and result of short-term and long-term trials with disease-modifying agents. Intl J Tissue Reactions 1992;14:243-51.

Shankland WE. The effects of glucosamine and chondroitin sulfate on osteoarthritis of the TMJ: a preliminary report of 50 patients. J Craniomandib Practice 1998;16:230-235.

Tannis AJ, et al. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12(6):506-511.

Tapadinhas MJ, et al. Oral glucosamine sulphate in the management of arthrosis: report of a multicentre open investigation in Portugal. Pharmacotherapeutica 1982;3:157-68.

Thie NM, et al. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. J Rheumatol 2001;28(6):1347-55.

Vajaradul Y. Double-blind clinical evaluation of intra-articular glucosamine in outpatients with gonarthrosis. Clin Ther 1981;3(5):336-343.

Vajranetra P. Clinical trial of glucosamine compounds for osteoarthrosis of knee joints. J Med Assoc Thai. 1984 Jul;67(7):409-418. Vas AL. Double-blind clinical evidence of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoporosis of the knee in out-patients. Current Med Research Opinions 1982;8:145-149.

MSM

Usha PR, Naidu MUR. Randomized, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004;24:353-363.

Kim LS, Axelrod LJ, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-294.

White Willow Bark

Chrubasik S, Kunzel O, et al. Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 2001;8:241-251.

Chrubasik S, Kunzel O, et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology 2001;40:1388-93.

Chrubasik S, Eisenberg E, et al. Treatment of low back pain exacerbation with willow bark extract: a randomized double-blind study. Am J Med 2000;109:9-14.

Schmid B, Ludtke R, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother Res 2001;15:344-350.

Ginger

Wigler I, Grotto I, et al. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-789.

Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis - significant superiority over the placebo group. Arthritis Rheum 2001;44:2531-8.

REFERENCES
Glucosamine

Bruyere O, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 2004;11(2):138-143.

Christgau S, et al. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol 2004;22(1):36-42.

Cibere J, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum 2004;51(5):738-745.

Clegg DO, Reda DJ, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808.

Crolle G, et al. Glucosamine sulphate for the management of arthrosis: a controlled clinical investigation. Curr Med Res Opin 1980;7(2):104-109.

D'Ambrosio E, et al. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2(8):504-508.

Drovanti A, et al. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a placebo-controlled double-blind investigation. Clin Ther 1980;3(4):260-272.

Giordano N, et al. Efficacy and safety of glucosamine sulfate in the treatment of gonarthritis. Clin Therapeutics 1996;147:99-115.

Herrero-Beaumont G, Ivorra JA, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum 2007;56:555-567.

Lopes Vas A. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8(3):145-9.

Muller-Fassbender H, et al. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2(1):61-69.

Mund-Hoym WD. Conservative treatment of vertebral osteoarthritis with glucosamine sulfate. Therapiewoche 1980;30:5922-28.

Noack W, et al. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2(1):51-59.

Pavelka K, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162(18):2113-23.

Pujalte JM, et al. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7(2):110-114.

Qui GX, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48(5):469-474.

Reginster JY, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001;357(9252):251-256.

Reichelt A, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study. Arzneimittelforschung 1994;44(1):75-80.

Rovati LC. The clinical profile of glucosamine sulfate as a selective symptom modifying drug in osterarthritis: current data and perspectives. Osteoarthritis Cartilage 1997;5:72.

Rovati LC. Clinical research in osteoarthritis design and result of short-term and long-term trials with disease-modifying agents. Intl J Tissue Reactions 1992;14:243-51.

Shankland WE. The effects of glucosamine and chondroitin sulfate on osteoarthritis of the TMJ: a preliminary report of 50 patients. J Craniomandib Practice 1998;16:230-235.

Tannis AJ, et al. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12(6):506-511.

Tapadinhas MJ, et al. Oral glucosamine sulphate in the management of arthrosis: report of a multicentre open investigation in Portugal. Pharmacotherapeutica 1982;3:157-68.

Thie NM, et al. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. J Rheumatol 2001;28(6):1347-55.

Vajaradul Y. Double-blind clinical evaluation of intra-articular glucosamine in outpatients with gonarthrosis. Clin Ther 1981;3(5):336-343.

Vajranetra P. Clinical trial of glucosamine compounds for osteoarthrosis of knee joints. J Med Assoc Thai. 1984 Jul;67(7):409-418. Vas AL. Double-blind clinical evidence of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoporosis of the knee in out-patients. Current Med Research Opinions 1982;8:145-149.

MSM

Usha PR, Naidu MUR. Randomized, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004;24:353-363.

Kim LS, Axelrod LJ, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-294.

White Willow Bark

Chrubasik S, Kunzel O, et al. Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 2001;8:241-251.

Chrubasik S, Kunzel O, et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology 2001;40:1388-93.

Chrubasik S, Eisenberg E, et al. Treatment of low back pain exacerbation with willow bark extract: a randomized double-blind study. Am J Med 2000;109:9-14.

Schmid B, Ludtke R, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother Res 2001;15:344-350.

Ginger

Wigler I, Grotto I, et al. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-789.

Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis - significant superiority over the placebo group. Arthritis Rheum 2001;44:2531-8.

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†These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure,or prevent any disease.